Polygenic influences associated with adolescent cognitive skills

Genes play an important role in children's cognitive ability through adolescence and into adulthood. Recent advances genomics have enabled us to test the effect of various genetic predispositions on measured outcomes. Here, we leveraged summary statistics from most recent genome-wide association studies eleven mental health traits build polygenic prediction models intelligence academic skills a cohort Australian adolescent twins (N = 2335, 57% female). We show that risk scores for educational attainment, intelligence, performance explained up 10% variance 7% our cohort. Additionally, found predisposition ADHD was negatively associated with all measures schizophrenia IQ but no other measure. In this study, provide evidence vulnerability some disorders is poorer variety tests, regardless whether individual has developed disorder.